Peter Thomas Roth Peptide Wrinkle-Fix Serum, Refillable — 2% Matrixyl & 5% Argireline for Firmer, Smoother Skin

Peptide Skinjection™ Amplified Wrinkle-Fix Serum is a refillable, peptide-dense topical serum designed to visibly smooth expression lines and support firmer-looking skin without needles.

This clinically advanced formula combines multiple targeted peptides at high actives percentages to address the appearance of dynamic lines and early loss of firmness. Packaged in a refillable dispenser, the serum is intended for daily topical use and can be used alone or as part of a professional injectable aftercare routine. The lightweight texture absorbs quickly and layers under moisturizers and makeup.

How does this serum work to reduce expression lines?

The product delivers a concentrated peptide complex that targets different mechanisms involved in expression lines. Each peptide has a distinct role—some support collagen-like responses, others modulate micro-contractions—so together they aim to visibly smooth lines over time with consistent use.

• Contains 2% Matrixyl Morphomics for skin-supporting signaling
• Includes 5% Argireline Amplified to address repetitive expression movements
• Provides 2% Matrixyl Synthe’6 to encourage a firmer appearance
• Boosted with 10% Argirelox™ peptide blend for sustained topical performance

Is the serum suitable for my skin type and routine?

This formula is designed for all skin types and is lightweight enough to fit into morning and evening regimens. It layers well under hydrators, sunscreens, and makeup, and can be paired with in-office treatments when advised by your skincare professional.

• Non-greasy texture absorbs quickly—suitable for oily to dry skin
• Can be used twice daily, morning and evening
• Works under moisturizers and makeup without pilling
• Refillable system reduces packaging waste and simplifies reordering

What evidence supports its performance and safety?

Clinical testing and in vivo studies were used during development to evaluate visible effects on expression lines and user tolerance. While individual results vary, study data indicated extended topical benefits for some participants when used consistently after professional neurotoxin treatment.

• Formulated with high-concentration peptide actives developed for topical application
• Tested in controlled studies; outcomes depend on individual skin and regimen
• Appropriate for use as part of a comprehensive anti-aging routine
• Designed for daily topical use rather than invasive procedures

How do I use the refillable bottle and integrate the refill?

The dispenser is engineered for convenient dosing and easy cartridge replacement to minimize waste. Apply a few drops to clean skin, gently pat over expression-prone areas, then follow with moisturizer and sunscreen during the day.

• Use on cleansed skin; apply 2–3 drops per area twice daily
• Allow full absorption before layering other products
• Replace cartridge when empty—follow included refill instructions
• Store upright in a cool, dry place away from direct sunlight

Who is this for: Ideal for adults seeking a non-invasive, peptide-forward approach to visibly reducing expression lines and supporting firmer-looking skin. It's a fit for those who prefer science-backed topical solutions, want a refillable packaging option, and wish to complement professional aesthetic treatments under the guidance of a skincare provider.

Ingredients

Water/Aqua/Eau, Dimethicone, Squalane, Butylene Glycol, Glycerin, Saccharomyces Lysate, Polysilicone-11, Acetyl Hexapeptide-8, Pentapeptide-18, N-Prolyl Palmitoyl Tripeptide-56 Acetate, Palmitoyl Tripeptide-38, Collagen, Sodium Hyaluronate, Tocopherol, Phytosterols, Hydrogenated Lecithin, Leuconostoc/Radish Root Ferment Filtrate, Citric Acid, Caprylic/Capric Triglyceride, Polyglyceryl-10 Myristate, Pentylene Glycol, Caprylyl Glycol, Sodium Benzoate, Sodium Phytate, Sodium Hydroxide, Potassium Sorbate, Ethylhexyl Palmitate, Hydroxypropyl Cyclodextrin Trihydroxystearin, Lauroyl Lysine, Glucomannan, Ethylhexylglycerin, Ammonium Acryloyldimethyltaurate/VP Copolymercarbomer, Glyceryl Stearate, Stearyl Alcohol, Behenyl Alcohol, Mica, Phenoxyethanol.